Obesity and Cigarethe Smoking are Two Modifiable Determination of Serum HDL Level in Tehran Urban Population "Tehran Lipid and Glucose Study"

Decreased serum HDL is one one of the most lonmon lipiu disoides in paterts with colonary disease and the existing enidenie svggests that every lmg/dl decreaie in servn HDL inveases CAD risk by 2-3 % . This study was performed in 2000 to study HDL deterninants in tehran popolation. westudied 9514 individvais, 20-69 yers old who have participated in tehran lipid and gwcose study (tl62), inclvding 3942 men and 5571 woman. in all subjects a personal history questionnaire especially on physical activity and cigarette smoking, was filled out and clinical examination inclvding anthroponetic measurements were performed. Serum levels of total cholesterol, trig;ucerides, and HDL were ,easured. Women had a significantly hoher mear HDL than in men (45± 11 vs 38±9 mg/dl; P<0.001); low HDL level (HDL < 35 mg/dl) was observed in 31 % of men and 13 % of women (P < 0. 00 I). Obese subjects (BMI 30 Kg/m2) had a significantly lower HDL level than normal subjects(42± 11 vs 44± 1 I: P < 0.0001). Subjects with truncal obesity (WHR0.95 in ,en and WHR 0.8 in women) had lower HDL level than normal subjects (37 ±9 vs 39± 10 in mean and 44± 11 vs 48± 11 in women  P < 0.001 in both). Smokers had a significantly lower HDL level than nonsmokers (38± 10 vs 43±11; P<0.001) and low HDL level was two ties more common in smokers than in nonsmokers (36.4 vs two times more common in smokers than in nonsmokers (36.4 vs 18.2 pecent). Passive smokers had also lower wean HDL levels ( 42 ± 11 vs 43 ± 11; P<0.001). Mean HDL level was not different in subjects with different degrees of physical acfiuity. In multiple stepwise logistic regression, deferminarts of serum HDL level, in order of entering the model, were: Sex (OR 3.03, P<0.001), high WHR (OR 1.56; P<0.001), Cigarethe smoking (OR 1.63; P<0.0001), age (OR 0.99; P<0.001), obesity (OR I. 21; P < 0. 005), and possive smoking (OR 1.17; P < 0. 04). Physical activity did not enter the predictive model apart from age and sex which are constitutional, nonmodifiable variables, other modifiable determinarts of HDL level (obesity, truncal obesity, cigareth smoking, and passive smoking) can be used in community prevention programs in control of CAD.